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KMID : 1144820200260010001
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대한의생명과학회지
2020 Volume.26 No. 1 p.1 ~ p.7
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Importance of Microglial Cytoskeleton and the Actin-interacting Proteins in Alzheimer's Disease
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Choi Go-Eun
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Abstract
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Alzheimer's disease (AD) is the most common neurodegenerative disorder and is expected to become more and more widespread as life expectancy increases. New therapeutic target, as well as the identification of mechanisms responsible for pathology, is urgently needed. Recently, microglial actin cytoskeleton has been proposed as a beneficial role in axon regeneration of brain injury. This review highlights in understanding of the characteristics of microglial actin cytoskeleton and discuss the role of specific actin-interacting proteins and receptors in AD. The precise mechanisms and functional aspects of motility by microglia require further study, and the regulation of microglial actin cytoskeleton might be a potential therapeutic strategy for neurological diseases.
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KEYWORD
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Alzheimer's disease, Microglia, Cytoskeleton, Actin filaments, Ionized calcium binding adapter molecules (Iba1), Cofilin 1 (CFL1)
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